Experimental Drug Raises Good Cholesterol Levels in Early Trial

Title: Experimental Drug Raises Good Cholesterol Levels in Early Trial Category: Health News Created: 11/17/2010 12:05:00 PM Last Editorial Review: 11/17/2010

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Cholesterol Levels In Middle Age Not Associated With Alzheimer’s Risk

A middle aged woman’s risk of developing Alzheimer’s disease later on in life does not appear to be affected by her levels of cholesterol, researchers from Johns Hopkins University School of Medicine wrote in the medical journal Neurology. The authors are now questioning previous research which did point towards a link. Significant drops on cholesterol levels during old age are much better predictors of Alzheimer’s risk, say the authors…

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Active ingredient levels vary among red yeast rice supplements

Different formulations of red yeast rice, a supplement marketed as a way to improve cholesterol levels, appear widely inconsistent in the amounts of active ingredients they contain, according to a report in the October 25 issue of Archives of Internal Medicine. In addition, one in three of 12 products studied had detectable levels of a potentially toxic compound.

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MicroRNA that may allow for better control cholesterol levels in blood identified

Scientists have identified an important microRNA that may allow us to better control cholesterol levels in blood. Their study found that the microRNA miR-33, may be key to controlling HDL, or “good” cholesterol levels.

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Cholesterol Levels – The Good, The Bad, and Management Of

What is cholesterol, and is it all bad? What’s the difference between LDL and HDL cholesterol? What are the healthy or normal cholesterol levels you should strive for?

In this article, I’ll explain what happens when your cholesterol levels aren’t normal, as well as some of the ways to manage them, so that you can be better educated and proactive where your health is concerned, and maybe even extend your life.

First of all, cholesterol is a waxy substance found in cells in all parts of the body. And no, it is not all bad. In fact, cholesterol is necessary for building and regenerating cells. It also insulates nerves and produces hormones in the body. The key is maintaining normal levels.

Where does cholesterol come from? About 75% of the cholesterol in our bodies is manufactured in the liver, and the other 25% comes from food, mostly meat and dairy products. If your liver produces too much cholesterol, that is when the levels become abnormal or unhealthy, and a method for bringing them back in balance becomes a necessity in order to preserve cardiovascular health.

This is especially important in people with diabetes, or metabolic syndrome (sometimes referred to as pre-diabetes.) Unhealthy cholesterol levels, when combined with weight gain and increased blood pressure, can lead to all kinds of health challenges.

IT IS IMPORTANT TO KNOW YOUR NUMBERS

Notice the plural, because it is not only total cholesterol or just the bad cholesterol number that is important. Complete cholesterol care implies being aware of all the numbers.

So what are the numbers you should know that make up the complete cholesterol picture?

First is the LDL or bad cholesterol. This is the component that when it becomes elevated, causes buildup on the walls of the arteries. As this buildup hardens, it becomes plaque, which increases your risk of cardiovascular disease (CVD). Science is proving that this buildup starts to develop in late teens and early twenties, and continues progressively as we age.

Of course as this buildup continues, it starts to narrow the opening in the arteries, restricting blood flow and raising blood pressure. Left unchecked, it can continue until it ruptures which causes a clot to form, totally cutting off the flow of blood.

If this clot is in the area leading to the heart, it is a heart attack. If it is in the arteries leading to the brain, that is a stroke. Both are considered cardiovascular disease.

LDL levels of greater than 190 are considered dangerous. 160 to 189 is considered poor, 130 to 159 is fair, and readings less than 129 are considered healthy. Some doctors are suggesting levels be below 100, and recent research is showing that if we can reduce our LDL to less than 70, we can actually start to reverse the plaque buildup.

The next number to be aware of is HDL, or the good cholesterol, which reduces your risk of CVD. In fact, your HDL number is becoming much more important because research has shown that for every 1% you reduce your LDL or bad cholesterol, you get about a 2% reduction in cardiovascular risk. But for every 1% you increase your HDL, you get a 3% reduction in risk. What should your HDL be? Healthy levels for men are above 40, and for women, it should be above 50.

Total Cholesterol or TC is the addition of your LDL, HDL and a component known as VLDL. Healthy levels are anything under 200. Another important number to be aware of is your cardiovascular risk ratio. This number is determined by dividing Total Cholesterol by HDL. This number should be below 5, with the optimal amount of 3.5 or lower.

Where do triglycerides come from? Fats consumed in our diet, or made in the body from carbohydrates, cause triglycerides in the blood. Some calories are converted to triglycerides and move into the fat cells for storage. So how do those numbers stack up?

Triglyceride levels of less than 150 are considered acceptable. Levels from 150 to 199 indicate moderate risk, 200 to 499 indicate high risk, and levels in excess of 500 indicate extreme high risk.

If it’s confusing to remember what’s good and what’s not, an easy way to remember the different parts of the total picture is “L” stands for “lethal” LDL, “H” stands for “healthy” HDL, and “T” stands for “treacherous” triglycerides.

METHODS FOR DEALING WITH UNHEALTHY CHOLESTEROL

There are different methods a person can use for improving one’s cholesterol levels. The most widely known is through the use of special cholesterol lowering prescription drugs called “statins”. Statins such as Lipitor, Zocor, Crestor, and others represent nationally a 25 Billion Dollar per year treatment option. They have proved themselves effective at lowering the LDL segment of the cholesterol picture, however they do very little to reduce triglycerides or raise the HDL.

Besides, statins sometime carry very significant side effects, and therefore some people can’t take them. What are some of these documented side effects?

The Statin Effects Study concluded that the top two are possible liver and muscle damage. However, there are also lesser known effects such as sudden memory loss, increase in eye cataract risk, suppresses the body’s natural immune function, increased cancer risk, kidney and nerve damage, depletes CoQ10 levels (necessary for healthy heart function), sleep disturbance, blood sugar or blood pressure changes, and sexual dysfunction.

According to the drug manufacturers, only an insignificant number of patients are affected by these side effects. But if you’re one of them, is it “insignificant” for you? What you will hear more and more from the drug companies, is that they also will admit that just lowering the LDL is not enough.

Combination therapy will become the new buzz word. It means adding additional drugs to raise the good cholesterol, or lower triglycerides or blood sugar. Of course, it’s highly likely that these additional drug additives will have their own set of additional side effects.

In fact, reports on the recent results of a clinical study by one of the leading pharmaceutical company’s combinations to try to raise the HDL led to “pulling the plug” on the whole experiment. Why, you ask? According to the report, an “unacceptable number of people died” while taking the combination therapy. Makes me wonder what number of people would be “acceptable”.

Do we see increased costs and co-pays in our futures? I believe you can bank on it. Some people feel, and I’m one of them, that even the cheapest co-pay is more than they’re willing to risk their quality of life for.

So are there other, safer alternatives for you? The answer is yes. In fact, according to the National Cholesterol Education Program (NCEP) guidelines for healthcare providers, statin drugs should not be the first treatment option offered. According to these guidelines, Therapeutic Lifestyle Changes (TLC) should be used as a first approach.

What are some of the features of TLC? Increase of soluble fiber, regular exercise, and weight reduction are the main ones. When it comes to diet, watch your fat intake, and eat more fruits and vegetables.

In addition to soluble fiber, other methods that can control cholesterol levels are the use of plant sterols or stanols, and a natural component called policosanol, from sugar cane, which blocks the enzyme in the liver that produces cholesterol. Statins block the same enzyme; however, the difference is that the policosanol does not damage the liver. Also ancient Chinese medicine has used a particular extract from the chrysanthemum plant to help in the breakdown of cholesterol.

If you’re concerned about safety and effectiveness, choose a natural solution with solid clinical evidence, that incorporates multiple methods, and raises HDL in addition to lowering LDL.

Be proactive in your own health, be educated on your cholesterol situation, make the right lifestyle choices, and you’ll improve your chances of living longer.

Additional information on lowering cholesterol can be found in “Your Guide to Lowering Cholesterol with TLC” by the US Nat’l Institutes of Health. NIH Publication 06-5235

Change Your Diet to Change Your Cholesterol Levels

Cholesterol is a soft way substance found in all parts of the human body. Some of the cholesterol is produced by the body and some of it comes from the food you eat. The body does need some cholesterol to function properly. Too much cholesterol can cause arteries to clog and can lead to heart disease. Maintaining a diet that is designed to reduce cholesterol levels can reduce risks of heart disease and lower cholesterol. Increasing physical activity and losing weight will help lower your cholesterol too.

Cholesterol can be found in eggs, dairy products, meat, and poultry. Egg yolks and organ meats like kidneys, liver, and sweetbreads are very high in cholesterol. Some shellfish are high in cholesterol but fish contains less cholesterol than that of other meats. Fat content of foods is not always the way to go to measure cholesterol in foods. Some times foods can be very low in fat and have high cholesterol content like liver. Foods of plant origin have no cholesterol like veggies and fruits.

To lower your high cholesterol levels you can limit your intake of fats to 25 to 35 % of the total day’s calories. Eating less than 200 mg’s of dietary cholesterol per day and getting more fiber in your diet can help to lower your cholesterol levels as well. It is still very important to get enough calories in your diet to support health.

A low cholesterol diet does not have to be hard to follow. There is such a huge variety of foods and ways to cook them that it would be hard to get bored. There are even many food companies that offer low fat and low cholesterol for people who don’t have time to put together large meals.

When shopping for food with your new diet in mind keep the following things in mind as well. Fruits and vegetables have no cholesterol in them. Lower the intake of saturated fats in your diet because these foods can raise your cholesterol levels. Partially hydrogenated vegetable oils contain a form of saturated fat called Trans fats. They raise blood cholesterol levels the same way saturated fats do. Trans fats are found in foods like margarines, shortenings, and cooking oils.

Whole grains should be used instead of foods with white flour. Eating large amounts of carbohydrates can raise cholesterol levels, especially if you have diabetes. Buying low fat or skim milk dairy products instead of whole milk products can help you lose weight along with decrease cholesterol levels. Lean meats like turkey, chicken, or fish are better for you rather than eating red meats. Instead of using ground beef using ground turkey is a healthy substitute for hamburgers or spaghetti. Olive and canola oils are lower in saturated fats which can help lower cholesterol.

Another great thing to add to a low cholesterol diet is an herbal supplement. Cholesterol Control is a product that can assist the body’s normal ability to balance cholesterol levels. Using this product with the diet and adding exercise to your daily routine can decrease bad levels of cholesterol. This product can be found at Alternative Health Supplements and is all natural and perfectly safe to use with no negative side affects.

How High Should Your Cholesterol Levels Be?

A 2007 report from the Women’s Health Study showed that high levels of cholesterol, even in healthy women, was a risk factor that increased a woman’s chances of having a stroke. Other studies have shown a link between high levels of cholesterol and Alzheimer’s disease. And the media has been warning us for years to cut down our intake of cholesterol because high cholesterol leads to hardening of the arteries. But what is cholesterol and why is it even it our bodies?

Cholesterol is a soft, waxy, fat-like substance that is made by the body. It is in all of your cells and can be found in all parts of the body including your skin, blood vessels, muscles, and so on. Since your body actively creates cholesterol, we can assume that having cholesterol in your body is not necessarily bad. In fact, you couldn’t eliminate all the cholesterol in your body if you tried.

Cholesterol is important for the body. The cells use cholesterol as a building block in creating its protective membrane. Studies have indicated that “good” HDL cholesterol protects against heart disease and stroke even if “bad” LDL cholesterol levels are high. Good cholesterol helps to prevent dangerous breakaway blood clots – which can be caused by sitting in a cramped position for too long. Cholesterol also helps to manufacture vitamin D in the body from the sun. And there is much more good that cholesterol does for the body.

There is also a second source of cholesterol. Dietary cholesterol comes form the foods that we eat. It can be only be found in animal foods and eating it raises the bad cholesterol level in your own body. There have been many studies over the years that correlate a high intake of dietary cholesterol to coronary heart disease. In other words, the more high cholesterol foods we eat, the greater our chance of developing heart disease or a stroke.

High density lipoprotein (HDL), the good cholesterol, is a form of cholesterol that circulates in the bloodstream. One of its jobs is to remove excess cholesterol from the body’s tissues and transport it to the liver where it will be excreted from the body. This process of “taking out the garbage” or cleansing the bloodstream is why HDL is a called good cholesterol and also why it’s good for your body to have a relatively high HDL level. Some researchers say that an HDL of 60 milligrams per deciliter (mg/dl) or greater is good and will protect you against hardening of the arteries and lower your risk of getting heart disease.

Conversely, a low level of HDL, such as less then 40 mg/dl, has a negative effect. Many studies indicate that a low level of HDL combined with a high level of LDL seems to be a precursor of heart disease

You can control your cholesterol. The total amount of cholesterol in your body at any point in time is a function of how fast your HDL and liver can cleanse your system of it’s existing cholesterol combined with the amount of dietary cholesterol that you’ve eaten during recent hours.

Controlling the amount of cholesterol that you allow into your body is a huge part of your lifestyle that you can modify to decrease your chances of heart disease or stroke. According to the American Heart Association, if you eat less then 300 milligrams of cholesterol a day, you can significantly reduce your cholesterol levels. By paying greater attention to the foods you eat, you can help to assure yourself of a long and healthy life.

Cholesterol Levels and Ratios – Are Your Cholesterol Numbers Confusing You?

Cholesterol levels are being tested all over the world in order to determine risk factors for heart disease, yet  many people are confused by their cholesterol numbers and how they are expressed.  Part of this confusion may stem from the fact that literature originating in the United States gives cholesterol levels in units that are different from those used in Canada, Europe, and a good portion of the rest of the developed world.  So when you are looking for information to help you understand your test results, on the internet and elsewhere, you might not  understand the numbers that are reported in the American literature because they might look quite different from the cholesterol numbers on your lab report.

The United States reports cholesterol levels in mg/dL (milligrams per decilitre) of blood.  The rest of the world is using the measurement called mmol (or millimoles per litre).  Without going back to basic chemistry from high school, let’s just say  that they are different measurements. So is it any wonder that these two ways of expressing your cholesterol numbers are so different?

Here is how the two different systems of measurement stack up for desirable cholesterol numbers.

As expressed in the system of measurement used in the United States

Total cholesterol = less than 200 mg/dL LDL  = less than 100-129 mg/dL (below 100 is best) HDL  = more than 40 mg/dL (greater than 60 is considered protective against heart disease)

However, as expressed in the SI units (International System of Measurement) that most of the world is using the numbers are stated differently. (You can remember which letters refer to the good and the bad stuff by remembering it this  way…H stands for healthy  and L stands for lousy.)

Total cholesterol = less than 5.2 mmol/L LDL  = in the range of than 2.6 – 3.3 mmol/L (less than 2.6 is best) HDL  = in the range of more than 1 to 1.5 mmol/L (higher is better) mmol/L

Can you see the difference in how the cholesterol numbers are expressed?  The difference of course is in the units that are being measured. Think of it like metric and imperial measures. Your weight in pounds might be a three digit number but in kilograms it could be a two digit number. Same weight different measurements.

Understanding the Cholesterol Ratio

When used to determine if you have cholesterol risk factors for heart disease it is not the specific levels that are analyzed but rather the ratio of HDL in your total lipid profile. This number is called the cholesterol ratio and it gives an indication of how much of your total cholesterol is the “good” stuff.

The reason this is important is because the HDL is so beneficial, if it is present is sufficient quantities it  has a protective effect and  the LDL in your system cannot do as much damage.  So even if your LDL is higher than the desired levels, if the HDL is high as well and the ratio comes within the desired range then the risk of heart disease is less.

The goal is to keep the cholesterol ratio below 5:1; the optimum ratio is 3.5. The cholesterol ratio comes in at the same number no matter which system of measurement is used. The cholesterol ratio is obtained by dividing the total cholesterol number by the value given for the HDL. For example, if a you have a total cholesterol of 240 mg/dL and an HDL of 60 mg/dL,  the ratio is 4. Using the SI system of measurement if the total cholesterol is 7.20 mmol/L and the HDL is 1.8 mmol/L  the ratio is still 4.

You can see how this is a better way of understanding the cholesterol risk factors for heart disease and expressing it this way can prevent confusion that might result from not being familiar with the units that are used. This information is also helpful for understanding why the strategies recommended  for cholesterol imbalances work. Some of the best strategies are the ones that raise the HDL levels.  In particular, exercise has been found to be one of the best ways to improve the cholesterol ratio because it raises HDL levels.  By contrast smoking has been found to lower HDL levels so no exercise and smoking is a recipe for low HDL levels, a poor cholesterol ratio, and a higher risk for heart disease.

Cholesterol is found in every cell of the body and is essential for the maintenance of good health.  Low cholesterol levels have been associated with poor health so the goal is not to eliminate or reduce cholesterol entirely but to obtain the desirable levels of each type so that the protective benefits of the HDL can work for you in maintaining good health.

So don’t get mixed up when trying to understand your cholesterol levels.  No matter what way the numbers are expressed the message is the same.  You want to have enough of the good stuff and not so much of the bad stuff in order to reduce your risk factors for heart disease.

Cholesterol Levels And Ratios – Are Cholesterol Numbers Confusing You?

Cholesterol levels are being tested as part of regular health screening all over the world yet many people are confused by their cholesterol numbers and how they are expressed. Part of this confusion may stem from the fact that most of the cholesterol literature is coming from the United States where they still report cholesterol levels in units that are different from those used in Canada, Europe and a good portion of the rest of the developed world. So if you are looking for information to help you understand your cholesterol test results you might not be able to understand the numbers that are reported in the American literature, that includes the internet.

The United States reports cholesterol levels in mg/dl (milligrams per decilitre) of blood. The rest of the world is using the measurement called mmol (or millimoles per litre). Without going back to basic chemistry from high school, suffice it to say that they are different measurements. So is it any wonder that these two ways of expressing your cholesterol numbers are so different?

Here is how the two different systems of measurement stack up for desirable cholesterol levels.

* Total cholesterol = less than 200 mg/dL
* LDL = less than 100-129 mg/dL (below 100 is best)
* HDL = more than 40 mg/dL (greater than 60 is considered protective against heart disease)

However, as expressed in the SI units (International System of Measurement) that most of the world is using the numbers are stated differently. (You can remember which letters refer to healthy and lousy by remembering it this way…H stands for healthy lipoprotein and L stands for lousy lipoprotein.)

* Total cholesterol = less than 5.2 mmol/L
* LDL = in the range of than 2.6 – 3.3 mmol/L (less than 2.6 is best)
* HDL = in the range of more than 1 to 1.5 mmol/L (higher is better) mmol/L

Can you see the difference in how the cholesterol numbers are expressed? The difference of course is in the units that are being measured.

Think of it like metric and imperial measures. Your weight in pounds might be a three digit number but in kilograms it could be a two digit number. Same weight different measurements.

When used to determine risk of heart disease it is not the specific cholesterol levels that are analyzed but rather the ratio of HDL in your total lipid profile. This number is called the cholesterol ratio and it gives an indication of how much of your total cholesterol is the “good stuff”.

The reason that the ratio is important is because the HDL (good stuff) is so beneficial that it can protect you from the effects of the LDL if it is in your body in sufficient quantities. So even if your LDL is higher that desirable levels, if the HDL is high as well, if the ratio comes within the desired range then the risk to your health is less.

The goal is to keep the cholesterol ratio below 5:1; the optimum ratio is 3.5. The cholesterol ratio comes in at the same number no matter which system of measurement is used to express the specific cholesterol levels.

The cholesterol ratio is obtained by dividing the total cholesterol number by the value given for the HDL. For example, if a person has a total cholesterol of 240 mg/dL and an HDL of 60 mg/dL, the ratio would be 4.

Using the SI system of measurement if the total cholesterol is 7.20 mmol/L and the HDL is 1.8 mmol/L the ratio is still 4.

You can see how this is a better way of understanding risk and prevents confusion that might result from not being familiar with the units that are used to express cholesterol levels.

This information is also helpful for understanding why the strategies why the for cholesterol imbalances work. Some of the best strategies are the ones that raise the HDL levels. In particular, exercise has been found to be one of the best ways to improve the cholesterol ratio because it raises HDL levels. By contrast smoking has been found to lower HDL levels so no exercise and smoking is a recipe for low HDL levels, a poor cholesterol ratio, and a higher risk of heart disease.

Cholesterol is found in every cell of the body and is essential for the maintenance of good health. Low cholesterol levels have been associated with poor health so the goal is not to eliminate or reduce cholesterol entirely but to establish the desirable levels of each type of cholesterol so that the protective benefits of the HDL can work for you in maintaining good health.

So don’t get mixed up when trying to understand you cholesterol levels. No matter what way the numbers are expressed the message is the same. You want to have enough of the good stuff and not so much of the bad stuff!

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