Here’s your liver cure
Many people I know who have high cholesterol are very careful about the amount of fat they eat. They almost go on a fat-free diet to bring their bad cholesterol under control. Still, their cholesterol stays out of balance. Here’s why, answers Dr Shikha Sharma.
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Cholesterol regulator plays key role in development of liver fibrosis
Scientists have found that a key regulator of cholesterol and fat metabolism in the liver also plays an important role in the development of liver fibrosis – the build-up of collagen scar tissue that can develop into cirrhosis.
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Study finds cholesterol regulator plays key role in development of liver scarring, cirrhosis
UCLA researchers have demonstrated that a key regulator of cholesterol and fat metabolism in the liver also plays an important role in the development of liver fibrosis — the build-up of collagen scar tissue that can develop into cirrhosis. Cirrhosis, in turn, is a major cause of premature death and is incurable without a liver transplant.
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Statin drugs cause liver damage, kidney failure and cataracts, says BMJ
(NaturalNews) Cholesterol-lowering statin drugs significantly increase a person’s risk of cataracts, muscle weakness, liver dysfunction and kidney failure, according to a study in the British Medical Journal . The study also confirmed that the drugs lower the risk of heart disease and esophageal cancer, but claims of other health benefits were unsupported. Researchers from Nottingham University in the United Kingdom examined data on more than 2 million patients between the ages of 30 and 84, seen at 38 different general practices, who had been prescribed the cholesterol-lowering drugs. More than 70 percent were taking simvastatin (Zocor), 22.3 percent were taking atorvastatin (Lipitor), 3.6 percent were taking pravastatin (Pravachol, Selektine), 1.9 percent were taking rosuvastatin (Crestor) and 1.4 percent were taking fluvastatin (Canef, Lescol, Lochol, Vastin). The researchers confirmed prior data suggesting that statins increase patients’ risk of cataracts, liver dysfunction, kidney failure and a form of muscle weakness known as myopathy. They found that for every 10,000 women treated with the drugs, 23 would develop acute kidney (renal) failure, 39 would develop myopathy, 74 would develop liver dysfunction and 309 would develop cataracts. Men suffered an even higher risk of myopathy, but their risks of the other three conditions were similar to those suffered by women. Putting it in different terms, the researchers found that only 434 people would need to be treated with the drugs for five years for one case of acute renal failure to develop. It would take only 136 treated for each case of liver dysfunction and 33 for each case of cataracts. Among women, 259 would need to be treated for each case of myopathy; among men, the number was only 91. The risk of developing all conditions was highest during the first year of treatment, but continued throughout the course of the study. Risk of liver and kidney problems increased proportionally with the dose of statins being taken. All drugs appeared to pose a similar risk of all conditions, with the exception of fluvastatin, which increased the risk of liver dysfunction more than its competitors. Men taking fluvastatin were twice as likely to develop liver dysfunction as those not taking statins, while women’s risk increased by 2.5 times. The researchers did find, however, that the risk of cataracts returned to normal within one year of stopping statin treatment, while the risk of liver and kidney problems returned to normal within one to three years. Additionally, they found no connection between statin use and the risk of dementia, osteoporotic fracture, Parkinson’s disease, rheumatoid arthritis or venous thromboembolism. Examining the purported benefits of the drugs, researchers found that they did in fact lower the risk of heart disease, averting 271 cases for every 10,000 high-risk patients treated. Put another way, 33 high-risk men or 37 high-risk women would need to be treated with the drugs to avert one case of the disease. Although advocates of the drugs have claimed that they may also reduce the risk cancer, the researchers found almost no data supporting these claims. The study “largely confirmed other studies that reported no clear association between statins and risk of cancers,” the researchers wrote. The only cancer-fighting effect uncovered in the study was a slightly lower risk of esophageal cancer, with eight cases averted for every 10,000 high-risk women treated. In other words, 1,266 high-risk women or 1,082 high-risk men would need to be treated with the drugs to prevent one case of esophageal cancer. Although sales of the blockbuster drugs are unlikely to be reduced as a result of the study, the researchers encouraged closer monitoring of patients for side effects and said their findings “would tend to support a policy of using lower doses of statins in people at high risk of the adverse event.” Sources for this story include: http://www.reuters.com/article/idUSTRE64J7B820100520; http://www.medpagetoday.com/Cardiology/Atherosclerosis/20232.
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Lower Cholesterol And Boost Liver Function With The Ayurvedic Herb Guggul
Guggul is gum resin that can be used to lower cholesterol and boost your liver function, though it has been used for thousands of years in India to treat a number of diseases and conditions. However, its mode of action is completely different to that of most other cholesterol lowering agents.
The active ingredient is known as guggulsterone, which is a plant sterol that increases the amount of body cholesterol into bile acids by the liver. Bile acids are an essential part of our digestion system, working to emulsify the oils and fats we eat and covert them into a form suitable for transferring to the blood and use elsewhere in the body. They also help the body make use of fat soluble vitamins such as vitamins A and E.
The resin used in this Ayurvedic remedy comes from the stem of a tree called Mukul myrrh that grows throughout India. Ayurvedic medicine is said to have originated from ancient Hindu texts, but is now thought to have evolved over thousands of years. The basis of the medicine is contained in two Sanskrit texts written on palm leaves and form the basis of modern Ayurvedic training. Guggul has been used for millennia in the treatment of skin conditions, rheumatism, arthritis, cardiovascular problems and high cholesterol.
Being an oily fat, cholesterol is not soluble in blood plasma and hence cannot be carried around the body without a carrier. These carriers are known as low density lipoproteins and high density lipoproteins. The LDL carries cholesterol to where it is needed by the body, and is a sticky substance that can also deposit cholesterol in the arteries that are carrying it. This can form a hard coating on the inside of the arteries called plaque, and effectively narrow them and harden them up.
This atherosclerosis, as it is called, is a dangerous condition, and if a blood clot encounters the narrow part of an artery so affected it can be blocked. If in the heart, then this can cause a heart attack, and if in the brain it can give rise to a stroke, both potentially fatal conditions.
HDL, on the other hand, carries excess cholesterol back to the liver for destruction or conversion to bile, and is a free flowing liquid material known as ‘good cholesterol’. Cholesterol is needed by the body and so cannot be eliminated completely. That would be even more dangerous. One of the major functions of cholesterol in the liver is in the production of bile that is used by your digestive process to emulsify fats. Any compound that could also carry out this vital function would mean that liver would have less cholesterol to manufacture.
Your body receives a dietary supply of cholesterol from fatty animal sources such as meat, fats, eggs and dairy products such as cheese and butter. There is no cholesterol in purely vegetable foods. However, that does not mean that vegans have no cholesterol, since as stated earlier, it is an essential substance in the body’s metabolism. In fact, the liver is able to generate all the cholesterol you need, and that which is taken in your diet is superfluous.
The liver can manufacture cholesterol from the trans and saturated fats in your diet, and there are several sources of these. Included among them are popcorn, vegetable shortening such as found in cookies and donuts and other manufactured bakery products made from hydrogenated margarines and oils widely used in the bakery industry. Also from rapeseed and palm oils and coconuts. Saturated fats are also contained in French fries and similar fried foods using certain vegetable oils, and also potato chips. Even vegetarians and vegans can suffer from high cholesterol levels.
Cholesterol is manufactured in the liver and taken up by LDL for distribution by the blood. However, a large proportion of that cholesterol is used by the liver to manufacture bile, essential for digestion of fats. This bile is stored in the gall bladder, and released into the upper intestine on the ingestion of fatty food. The bile acids and fats pass down the intestine, where the fats are emulsified into a form suitable for absorption by the body.
The bile acids are then absorbed in the final part of the ileum by proteins that carry them back to the liver where they are recirculated into the bile. Once the level of bile acids in the body reaches a certain level, a chemical known as the Farnesoid X Receptor (FXR) stops the liver from converting cholesterol into bile. Although only 5% of the bile is excreted from the body and needs replaced, this still accounts for 50% of the body’s usage of cholesterol.
The production of bile from cholesterol operates on a closed loop system, with a feedback that maintains a constant level of bile acids. The feedback is controlled by FXR that detects the current level of bile acids and represses the enzyme (CYP7A1) that stimulates bile manufacture until a minimum level has been reached when the CYP7A1 is re-activated.
By blocking the action of FXR, the guggulsterone in guggul continues the conversion of cholesterol to bile acids by the liver without interruption. The liver has to use more LDL cholesterol for this and so reduces the overall amount of cholesterol in the body, specifically the LDL type.
A double blind study in India showed a total cholesterol reduction of 11.7%, including a 12.7% reduction in LDL and a 12% reduction in blood fat (triglyceride) levels, and other studies have indicated a total cholesterol reduction of up to 27% and triglycerides of up to 30%. The Indians believe guggul to be so effective that is has been approved as a treatment for high cholesterol by the Indian government. The connection with FXR has been confirmed by testing with mice with and without FXR.
Another factor in high cholesterol levels is that an under-active thyroid can interfere with the liver’s ability to process cholesterol. Guggul stimulates then production of thyroid hormones, and so can help to reduce excessive LDL cholesterol in the blood cause through a low level of thyroid hormone production.
Overall, then, this Ayurvedic remedy for many ills can help anyone who needs to reduce the level of cholesterol and triglycerides in their blood. Recommended dosages are about 1500 mg twice daily, though if you are also taking statins or are under treatment for cancer you should first consult your doctor, as you should with all natural remedies that are new to you.
More information can be found at http://vitanetonline.com/ where a large selection of Ayurvedic remedies like guggul are available.
Get Information About Cholesterol
Cholesterol is a fatty substance (a lipid) that is an important part of the outer lining (membrane) of cells in the body of animals. Cholesterol is also found in the blood circulation of humans. The cholesterol in a person’s blood originates from two major sources; dietary intake and liver production. Dietary cholesterol comes mainly from meat, poultry, fish, and dairy products. Organ meats, such as liver, are especially high in cholesterol content, while foods of plant origin contain no cholesterol.
Blood cholesterol level is affected by the diet, since cholesterol is present in certain foods and is manufactured in the body from digested fats. High levels of cholesterol in the blood are associated with hardened arteries (known as atherosclerosis), coronary artery disease (heart attack), and stroke.
There are many types of cholesterol. LDL or Low-density lipoprotein is the “bad” cholesterol, as it blocks the arteries. HDL or High-density lipoprotein is the “good” cholesterol, as it protects the arteries from clogging.
Diets should contain less than 30% calories from fat, less than 8% from saturated fat, and enriched in marine or plant omega-3 fatty acids. Avoid high saturated fats, like diary fats (ice cream, butter) and palm and coconut oils. Limit high cholesterol foods, like eggs and organ meats (liver). Eat higher fiber foods, fruit and vegetables. Eat more fish and skinless chicken breasts. Avoid fried foods and frying which soaks up the fat . Choose low fat and non-fat dairy products, avoid hard margarines which have trans-fatty acids, and try to use products made from plants instead.
Cholesterol really assists the system by creating original cells, aiding in the output of hormones, and insulating the numerous nerves that operate throughout the system. High cholesterol rates are alarmingly growing. Cholesterol may be accounted for higher blood force and coronary eye diseases but not all of these oily substances are detrimental. There are the terrible and better cholesterol. The better cholesterol aids in bile salts output and vitamin D formations. In fact, cholesterol portrays a character of balancing hormones especially among women. Health professionals are trying urgently to offer extreme solutions to the matter.
High blood cholesterol is one of the major risk factors for coronary heart disease, and it is a risk factor you can modify. Knowing your total cholesterol, HDL, LDL, and triglyceride levels is an important first step in determining your risk for heart disease. Left undiagnosed or untreated, a high blood cholesterol level, as well as other coronary risk factors, can lead to possible serious cardiovascular problems in the future.
Get physical, do regular physical activities and exercises more often. The wonders of exercise are indeed very essential in lowering high cholesterol levels. Doing regular physical activities can also help raise the good cholesterol levels and lose weight as well. There’s really no need for high-intensity workouts, regular brisk walking or jogging can help the body boost HDL cholesterol and also beneficial for the heart.
Medications for cholesterol are most often long-term medications. They have to be taken everyday, often for the rest of your life. Drugs that are most often prescribed are the statins. Statins help the liver remove LDL cholesterol, and reduce production of cholesterol.
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Diet to Lower Cholesterol – A Simple Explanation of Just What is Cholesterol
Many people understand that cholesterol is either bad for you or good but beyond that, they do not understand just exactly what is cholesterol. Doctors will give you a long explanation which only they can comprehend but cholesterol can be simplified in one statement. Cholesterol is a waxy material that the liver fabricates which is carries out a number of responsibilities for the health of our bodies.
When we consume foods in our daily diet, our liver takes the food and turns it into cholesterol which helps aid in developing bile salts to digest the fat, build cell walls, and to create vitamin D. So why would we worry about eating too many foods that produce too much cholesterol in our body? The answer lies in the fact that too much of anything is essentially bad for you. If we understand what is cholesterol, we can better steer clear of consuming to much cholesterol.
The Bad And Good Cholesterol.
One easy way to watch our cholesterol level is to understand what foods that we eat in our daily diet which produce the good cholesterol bad cholesterol. Foods that carry animal fat such as dairy and meats carry bad cholesterol, Foods such as vegetables, fruits, and whole grains carry no cholesterol at all.
When we eat foods that have too much bad cholesterol it can cause some major damage such as the hardening of our arteries. This occurs when too much bad cholesterol is in our system because it builds up plaque which blocks the arteries and prevents blood flow.
Good cholesterol behaves very differently than bad cholesterol because its main goal to keep our bodies healthy. What the good cholesterol does is carry the surplus of cholesterol we have in our bodies to the liver so it can create bile salt and expel it from our system.
High Cholesterol Is Caused By What?
When we ask our doctor about our cholesterol level, it is usually because we are worried about having a high cholesterol level. Having a high cholesterol level can be caused for many different reasons but the main cause is age. You see, our cholesterol level goes up as we get older.
There are many things that can cause us to get high cholesterol levels. One thing is we may inherit from our parents. If your parents have high cholesterol, you should ask your doctor to be tested to make sure if you have it or not. Another thing is doing physical activity. When we exercise and do any other physical activity, this causes our good cholesterol levels to rise thus keeping us healthy.
When we are looking at the causes and cures for high cholesterol, we often find a direct link between the food we eat and our cholesterol levels. If we eat foods rich in fiber, vegetables, beans, fish, and fruits we can keep the good cholesterol levels up within our body. We also need to try and avoid eating foods that promote high cholesterol levels within our body like meat and dairy products.When we go to the doctor and he gives us our cholesterol reading, many do not understand just exactly what he is talking about. Many people know that cholesterol is either good for you or bad, but many do not understand what is cholesterol. Cholesterol is simply a waxy matter that the liver creates which handles a number of duties in our body.
Author: Delynda Lardone
Article Source: EzineArticles.com
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Optimum Cholesterol Levels for Liver Health
Typically assumed to inflict solely negative consequences, cholesterol is actually a necessary component of a healthy body. Cholesterol is a waxy substance in the blood, critical in the digestion of dietary fats, the building of cell walls and in manufacturing vitamins and hormones. One of the secrets to securing a healthy body, including a healthy liver, is to maintain an ideal balance of cholesterol levels.
If cholesterol levels are too high, a person is at risk for coronary artery disease, heart disease, a metabolic disorder or even liver disease. Embedded in vehicles known as lipoproteins, cholesterol is transported in the bloodstream to be used or excreted throughout the body. When these inhabitants of our blood become overpopulated, traffic jams can result, blocking subsequent blood flow in the vessels. Impeded circulation is a primary factor in most types of illness.
Cholesterol and the Liver
Excessive cholesterol in the blood can deposit plaques along the vessels, contributing to the development of atherosclerosis, the hardening of the arteries. While atherosclerosis is a leading cause of heart attacks and strokes, it can also have negative consequences on the liver. The relationship between the liver and blood cholesterol is multi-faceted:
· Synthesis of bile acids – Essential to the digestive process, the liver synthesizes bile acids from cholesterol. Bile acids emulsify dietary fat, allowing for its absorption in the intestines.
· Liver circulation – Liver disease, particularly cirrhosis, can lead to portal hypertension. Portal hypertension is the result of high blood pressure within the portal vein, where the blood enters the liver. When blood cannot flow easily through the liver, internal pressure increases, posing the risk of ruptured blood vessels. Cholesterol deposits may also contribute to decreased blood flow in the liver, further restricting the vessels that safely handle the liver’s duties.
· Removal of cholesterol – High-density lipoproteins (HDL) help remove excessive cholesterol from the body by transporting it to the liver for its breakdown and excretion. As a diseased liver’s function decreases, do does its ability to remove excessive cholesterol from the blood supply.
What is Excessive Cholesterol?
According to the American Heart Association, about 20 percent of the U.S. population has high blood cholesterol levels. When getting your cholesterol checked, there are four numeric values that come into play – total cholesterol, LDL (low-density lipoproteins), HDL (high-density lipoproteins) and triglycerides.
· Total Cholesterol – A comprehensive measurement of the cholesterol in your blood, it is desirable to have a value less than 200 mg/dL. A person carries a borderline level of health risks if the total cholesterol is between 200-239 mg/dL, and is considered high risk if total cholesterol exceeds 239 mg/dL.
· LDL – This cholesterol is the primary cause of harmful fatty buildup in arteries. The higher the LDL cholesterol levels in the blood, the greater the health risk. Ideal LDL levels are below 100 mg/dL, while values exceeding 159 mg/dL carry a high risk of cardiovascular disease.
· HDL – This form carries blood cholesterol back to the liver, where it can be eliminated. HDL helps prevent a cholesterol buildup in blood vessels. While values typically range from 40 to 60 mg/dL, an HDL under 40 mg/dL puts the individual at risk for cardiovascular disease. Studies suggest that high levels of HDL cholesterol reduce your risk of heart attack.
· Triglycerides – Triglycerides are the chemical form in which most fat exists in food as well as in the body. Triglyceride levels under 150 mg/dL are normal, while values exceeding 199 mg/dL carry a high risk of cardiovascular disease.
Due to the delicate balance of useful cholesterol and damaging cholesterol, most physicians rely on specific ratios of these four numeric values to determine healthy blood cholesterol.
Liver Benefits from Good Cholesterol Ratio
The public is being increasingly educated on the various ways to maintain the best possible cholesterol levels. These include lifestyle modifications, such as smoking cessation, regular exercise, a diet high in fiber and low in saturated fat, as well as reliance on cholesterol lowering medications.
Awareness of cardiovascular risk by improving your cholesterol ratio will benefit not only your heart’s health, but also your liver’s health. While the heart muscle pumps blood throughout the body, the liver must cleanse the blood and extract ingredients critical to sustaining life.
Just as the heart and liver contribute to blood maintenance health, all of our organs and body systems work in unison to support the proper functioning of our bodies. Factors that affect one system will likely affect every other. So if optimal liver health is desired, then steps to increase HDL and decrease LDL and triglycerides are definitely called for.
References:
Henkel, John, Keeping Cholesterol Under Control, FDA Consumer Magazine, January/February 1999.
http://www.abouthypertension.info, Health Issues Associated with Hypertension, NCERx LLC 2006.
http://www.americanheart.org, About Cholesterol, American Heart Association, Inc., 2006.
http://www.liverdisease.com, Cholesterol and Liver Disease/Hepatitis, Melissa Palmer, MD, 2004.
Author: Nicole Cutler
Article Source: EzineArticles.com
Provided by: Cellphone news
Cholesterol BAD?
The first thought that comes to a person’s mind when buying something with high cholesterol level would be “NO! I don’t want to end my life with a heart attack!!” They are probably right but CAN THEY POSSIBLY LIVE WITH NO CHOLESTEROL AT ALL? Cholesterol is the cause of number of diseases related to heart but on the other side it is an essential sterol that gets converted to other steroid hormones. Not to mention that the cholesterol intake level of a person is proportional inversely to the cholesterol synthesized by the body itself. So is cholesterol really a nightmare or is this just another misconception?
Cholesterol is a lipid found in the tissues of all the animals, associated with other sterols. It is the best known member of the biological group – sterol, a combination of steroid and an alcohol. Most of the cholesterol is produced inside the body and only a minute quantity has dietary origin.
Almost of 20-25% of the total daily production occurs in the liver. The other sites include the intestines, suprarenal glands and reproductive organs. This cholesterol is either converted to other hormones, transported to cell that require cholesterol or secreted via bile into the intestines. Of the cholesterol poured into the intestines, 92-97% is reabsorbed in the intestines and recycled via the enterohepatic circulation. The cholesterol, insoluble in blood, of the diet is transported to the liver from the intestines, where it is absorbed, within the lipoproteins – chilomicrons, Very Low Density Proteins (VLDL), Intermediate Density Lipoproteins (IDL), Low Density Lipoprotein (LDL) & High Density Lipoproteins (HDL).
Cholesterol is mainly obtained from food having saturated fatty acids and is also synthesized from acetate inside the body. Normally the total amount of cholesterol from these two sources remains constant because the rate of cholesterol synthesis in the liver is under feedback control. When the dietary intake is high, liver synthesis is low; when intake is low, synthesis increases.
LDL is the major transport protein for cholesterol, supplying both free and esterified cholesterol to body tissues. High Density Lipoprotein (HDL) is involved in the transport of cholesterol to the liver to be broken down and excreted, and in removing some LDL cholesterol from artery walls. The esterified cholesterol is essential for a cell to maintain the fluidity of membrane over a wide range of temperature, so the cells use this esterified cholesterol for its maintenance. If the cholesterol is not esterified, the cells pushes it and the free cholesterol comes in the cholesterol, which sometimes along with Ca++ accumulates in the capillaries causing embolus formation and coronary obstruction.
The significance of cholesterol cannot be neglected. Some researched indicate that cholesterol might be used as an anti-oxidant. Besides that it also maintains the fluidity of the cell membranes. The cholesterol content of a membrane varies with the tissue and with specific membrane function. The ratio of cholesterol to polar lipids affects the stability, permeability, and protein mobility of a membrane. Membranes with high ratios have high stability and relatively low permeability; their major function is a protective barrier.
They serve primarily in synthetic and degradative reactions and energy production. It also reduces the permeability of hydrogen and sodium ions. In addition to its role in membrane structure cholesterol has other important functions. Cholesterol is stored in the adrenals, testes, and ovaries, chiefly as the fatty acid ester, and converted to steroid hormones. These hormones include the male and female sex hormones (androgens and estrogens) as well as the adrenal corticoids (cortisol, corticosterone, aldosterone, and others). In the liver cholesterol is the precursor of the bile acids, 24 steroid carboxylic acids that aid in the digestion of foods, especially lipids, and, when linked with the amino acids glycine or taurine, form the bile salts. Recently it has been suggested that cholesterol assists in the formation of lipid rafts in the membrane.
Besides the numerous functions of cholesterol, high free cholesterol level in the blood can cause life threatening problems as well. As mentioned above LDL is involved in the transportation of cholesterol. But high levels of LDL or free cholesterol in the blood causes the cholesterol to deposit in the blood capillaries hence narrowing the lumen of the vessels. The narrowed vessels increase the blood pressure and may lead to its rupture and ultimately causing an embolus. In the brain, it causes cerebro-vascular accidents and in heart it causes Ischemic Heart Disease. High LDL level are major cause for the arthrosclerosis of the arteries, leading to coronary heart disease and other forms of cardiovascular disease. However increase levels of HDL not only transport cholesterol to the liver to be broken down and excreted but also remove LDL cholesterol from the artery walls.
It has been suggested that abnormally low levels of cholesterol might cause depression, cancer and cerebral hemorrhage but it unclear whether cholesterol itself is responsible for it or something else associated with low levels of cholesterol. Esterified cholesterol when crystallizes in the gall bladder, is the major cause of formation of gall stones which leads to severe pain in near the liver region.
Cholesterol is present in many dietary components that we consume daily. This cholesterol is called the dietary cholesterol. Its percentage is significantly higher in animal fats (saturated fats), eggs, yolks, beef, poultry, liver, kidneys, and shrimps. Besides these, plants and fungi also contain trace amounts of cholesterol so even a vegetarian’s diet has cholesterol in it but in trace amounts.
Although the intake level of cholesterol must be kept low but not so low so as to lead to its deficiency which would the affect the normal anatomical and physiological state of the body. Since the total cholesterol level in the body almost always remains same so people with higher cholesterol intake maybe at the same risk of having a heart attack as those with lower cholesterol intake. An effective way to keep the cholesterol balance healthful and beneficial to the body is by exercising regularly whether walking, sprinting, or working out in the gym. With this, the benefits of cholesterol would dominate its harms and the body would function normally at its optimum performance.
Author: Umar Majeed
Article Source: EzineArticles.com
Provided by: Programmable Multi-cooker
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